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Introduction to CO2 Fractional Laser Therapy

CO2 fractional laser is a minimally invasive dermatological procedure that delivers precise thermal energy to the skin, stimulating collagen remodeling and tissue regeneration. This guide covers indications, pre/post-treatment protocols, and expected outcomes for practitioners and patients.


1. Clinical Applications

  • Skin Rejuvenation: Addresses fine lines, textural irregularities, and mild photodamage.
  • Scar Revision: Effective for acne scars, surgical scars, and stretch marks.
  • Hyperpigmentation: Targets solar lentigines and melasma (with caution in darker skin types).
  • Benign Lesions: Removes seborrheic keratoses and viral warts.

Contraindications: Active infections, keloid tendencies, or recent isotretinoin use (<6 months).


2. Pre-Treatment Preparation

  • Patient Assessment:
    • Fitzpatrick skin type classification (prefer types I-IV).
    • Detailed history of photosensitivity and medications.
  • Skin Preparation:
    • 4 weeks of sunscreen (SPF 30+).
    • Discontinue retinoids/chemical peels 1 week prior.

3. Procedure Parameters

ParameterTypical Range
Energy Density50–150 mJ/cm²
Fraction Density5–15%
Passes1–3
Anesthesia: Topical lidocaine cream (30–60 min application).

4. Post-Treatment Care

  • Immediate Phase (0–3 days):
    • Erythema and edema (cold compresses help).
    • Occlusive dressing (e.g., Vaseline) to prevent crusting.
  • Recovery Phase (4–7 days):
    • Gentle cleansers; avoid scrubbing.
    • Strict sun avoidance.

Expected Downtime: 3–7 days for re-epithelialization.


5. Complications & Management

  • Hypopigmentation: More common in darker skin types (manage with lower energy).
  • Infection: Rare; treat with topical antibiotics if signs appear.
  • Persistent Erythema: Usually resolves in 2–4 weeks.

6. Efficacy & Maintenance

Optimal results require 3–5 sessions spaced 4–6 weeks apart. Long-term maintenance may involve annual touch-ups.

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